We follow the Harmon family: Ben, Vivien, and Violet, who move from Boston to Los Angeles to start a new life in a Victorian mansion, after Vivien has a miscarriage and Ben has an affair with Hayden, one of his students. On arrival, they learn from Marcy, the real estate agent, that the previous owners of their new mansion, a couple named Chad and Patrick, died in an apparent murder/suicide. Their neighbor Constance and her daughter Addie become frequent, and sometimes unwelcome, guests. Addie seems to have a connection with the house's mysterious past. Larry Harvey, a former resident of the house who has suffered from horrible burns, also begins inserting himself into the Harmons' lives, giving Ben a cryptic warning about the house. The house also "comes with" Moira O'Hara, a housekeeper who appears young and seductive to men, but old and matronly to women. Ben begins seeing patients out of his home office. One in particular, a possibly psychotic teenage boy named Tate Langdon, takes interest in kindred spirit Violet, who suffers from depression. Ben is unaware that Tate is both a ghost and the son of Constance. As the family settles into the home, bizarre events begin to occur with increasing regularity. It is soon revealed that there have been upwards of 20 violent deaths in the home over the course of its history, so much so that it has come to be known as "The Murder House". The family struggles with their own personal tribulations, oblivious to the reality that their home is haunted by ghosts. While exploring the attic, Vivien discovers a latex bondage suit. She later has sex with a man wearing it, who she believes is Ben, but is actually Tate. Vivien's rape results in the rare occurrence of becoming pregnant with twins by different fathers.
We follow the patients, doctors, and nuns who occupy Briarcliff Mental Institution in Massachusetts in 1964. Sister Jude and Sister Mary Eunice maintain the institution that was founded by Monsignor Timothy Howard to treat and house the mentally and criminally insane. Psychiatrist Dr. Oliver Thredson, and scientist Dr. Arthur Arden, treat the patients within the facility. The patients include lesbian journalist Lana Winters, accused serial killer Kit Walker, and alleged murderer Grace Bertrand. Sister Jude was once a philandering nightclub singer who unintentionally killed a young girl in a drunk-driving hit and run accident in 1949. This led her to become a nun and she was later selected to work at Briarcliff. Sister Mary Eunice is a shy and innocent nun who fears Sister Jude. Later, she becomes possessed by the Devil during an exorcism of another patient and becomes cruel and willful. Sister Jude is terrorized by the memory and goes to see the family of the dead girl. While there, she learns the girl survived the accident with only a few broken bones. Sister Jude figures that God had a plan for her all along, and decides that it is her job to destroy all the remaining evil at Briarcliff. The evil includes the sadistic scientist Dr. Arden and the secret serial killer Dr. Thredson. Arden is a former Nazi whose experiments have produced "Raspers", mutated former patients, who lurk in the woods surrounding the institution, and who are fed the flesh of dead patients. Dr. Thredson is a psychiatrist assigned to evaluate Kit Walker, who believes his wife Alma was kidnapped by aliens. It is revealed that Thredson actually committed the murders, and got himself assigned to Walker’s case to make sure he could pin the murders and Alma's disappearance on him. Kit is duped into taping a confession and is arrested for the murders but later escapes custody. Thredson also tries to "reform" another patient, Lana Winters, an ambitious journalist who attempts to expose Briarcliff's mistreatments.
We follow a Coven of Salem descendants who reside within Miss Robichaux's Academy in New Orleans. Zoe Benson is sent to the Academy after discovering her dark power: she can magically induce brain hemorrhaging in any man by having sex with him. Upon arrival, she meets Madison Montgomery, a telekinetic and a recovering drug abuser who was once a child film star; Queenie, a descendant of Salem with the power to inflict wounds on others by harming herself, without feeling any pain; and Nan, an enigmatic clairvoyant who can hear the thoughts of others. The Academy is run by headmistress Cordelia Foxx, who has always lived in the shadow of her mother, Fiona Goode. Fiona is the Coven's "Supreme", a witch born every generation who embodies countless gifts and magical abilities, namely, the Seven Wonders of Witchcraft. The Academy is looked after by Spalding, a mute butler who has a mysterious relationship with Fiona. The Coven is assessed by the Council of Witchcraft, which includes Fiona's old rival and Cordelia's mother figure, Myrtle Snow. At a party, Zoe meets fraternity president Kyle Spencer, who takes a liking to her. Madison is gang-raped by Kyle's frat brothers and, as revenge, uses her power to flip their bus, killing Kyle and six others. Two of the boys survive and are placed in critical care. Zoe goes to the hospital and kills the remaining rapist with her power. To repay Zoe, Madison revives a dismembered Kyle by attaching his frat brothers' severed limbs to his head and casting a resurrection spell, but he returns frightened and simple-minded. It is revealed that Kyle's mother sexually abused him, making it hard for him to be trusting of physical touch. His revived corpse attracts Misty Day, a witch who resurrected herself after being burned at the stake. Meanwhile, Fiona is cursed with an untreatable cancer due to a new Supreme rising. She tries, in vain, to regain her youth and cure herself.
Set in Jupiter, Florida in 1952, we follow the lives of a troupe of people belonging to one of the last remaining freak shows of its time. Elsa Mars is the owner of Fräulein Elsa's Cabinet of Curiosities; and her performers the bearded lady Ethel Darling, her lobster-handed son Jimmy Darling, the strongman Dell Toledo and his three-breasted hermaphrodite wife Desiree Dupree, as well as the newly recruited conjoined twin sisters Bette and Dot Tattler. After their mother is found stabbed to death, Bette and Dot are discovered stabbed themselves at their farmhouse. The news makes headlines, and soon Elsa discovers the twins' existence. Believing the sisters to be her troupe's saviors, she brings them back to camp. They meet their fellow freaks Paul the Illustrated Seal who has seal-like flippers for hands, Amazon Eve who is the largest and strongest woman of the show, and finally the tiny performer from India, Ma Petite who is the smallest woman in the world. Bette sees the show as their haven but Dot believes that they are being exploited for their appearance. Meanwhile, serial killer Twisty the Clown is responsible for recent murders and kidnappings that plagued the town. A detective arrives at the freak show to arrest Bette and Dot for the recent string of murders. After calling them all freaks and threatening to drive them out of town, Jimmy kills the detective and the freaks dispose of his body. After a performance, which was bought out by a wealthy widow named Gloria Mott and her emotionally stunted son Dandy Mott, Dandy demands to buy the twins, offering Elsa $15,000, but she declines. Enraged by his boring life, Dandy sets out to join the freak show, but Jimmy turns him down. Hoping to cheer her son up, Gloria finds Twisty on the side of the road and brings him home to surprise Dandy. Dandy searches inside his bag and finds a severed head, causing Twisty to knock Dandy out and run away.
Set in Jupiter, Florida in 1952, we follow the lives of a troupe of people belonging to one of the last remaining freak shows of its time. Elsa Mars is the owner of Fräulein Elsa's Cabinet of Curiosities; and her performers the bearded lady Ethel Darling, her lobster-handed son Jimmy Darling, the strongman Dell Toledo and his three-breasted hermaphrodite wife Desiree Dupree, as well as the newly recruited conjoined twin sisters Bette and Dot Tattler. After their mother is found stabbed to death, Bette and Dot are discovered stabbed themselves at their farmhouse. The news makes headlines, and soon Elsa discovers the twins' existence. Believing the sisters to be her troupe's saviors, she brings them back to camp. They meet their fellow freaks Paul the Illustrated Seal who has seal-like flippers for hands, Amazon Eve who is the largest and strongest woman of the show, and finally the tiny performer from India, Ma Petite who is the smallest woman in the world. Bette sees the show as their haven but Dot believes that they are being exploited for their appearance. Meanwhile, serial killer Twisty the Clown is responsible for recent murders and kidnappings that plagued the town. A detective arrives at the freak show to arrest Bette and Dot for the recent string of murders. After calling them all freaks and threatening to drive them out of town, Jimmy kills the detective and the freaks dispose of his body. After a performance, which was bought out by a wealthy widow named Gloria Mott and her emotionally stunted son Dandy Mott, Dandy demands to buy the twins, offering Elsa $15,000, but she declines. Enraged by his boring life, Dandy sets out to join the freak show, but Jimmy turns him down. Hoping to cheer her son up, Gloria finds Twisty on the side of the road and brings him home to surprise Dandy. Dandy searches inside his bag and finds a severed head, causing Twisty to knock Dandy out and run away. Dandy follows him back to an abandoned school bus in the middle of the woods, where he discovers the kidnapped children and realizes the two can work together.